I wish I could help more, but the only thing I've ever used beside the Borg set is the MACO sets. Unless you are counting those under what you meant since it comes from the Borg Rep. Which I always liked it so when the other reps came out, I didn't feel the need to get them based on the boost and bonus. I would blend Adapted MACO engine and shields with MACO deflector because it gave good bonus to shields, torps, aux, and your crew resist.
On my new ship I thought about branching out to the newer reps to explore more Science oriented sets, however I threw my Aegis set on there I hadn't touched in years. It's been working so good I've decided to stick with it.